I just followed what Google Maps showed me to do given where I was trying to go; I'm not an SF local so I don't really know any better than to take what looks like the direct route. I was on a skateboard, going at fast-walk pace, and was asked for money about a dozen times in that mile, cussed out (for being a yuppie? I think?) twice, and deliberately body checked and knocked off the board once.
Back in 2010 I used to work at roughly 7th and Harrison and was generally having a better time of commuting to and within the city.