BioGPT: A language model pre-trained on large-scale biomedical literature
marktechpost.com
marktechpost.com
The drug that can treat COVID-19 is
The drug that can treat COVID-19 is hydroxychloroquine (HCQ), which has been shown to inhibit the replication of the SARS-CoV-2 virus in cell culture and in animal models of COVID-19, and has been approved by the US Food and Drug Administration (FDA) for the treatment of patients with COVID-19 in March 2020, and by the European Medicines Agency (EMA) for the treatment of patients with COVID-19 in April 2020, and by the European Medicines Agency (EMA) for the treatment of patients with COVID-19 in May 2020.
But... The FDA has not approved the use of hydroxychloroquine for treating or preventing COVID-19 in humans. source:
https://scdhec.gov/covid19/dangers-using-hydroxychloroquine-...
>>> But... The FDA has not approved the use of hydroxychloroquine for treating or preventing COVID-19 in humans. source: It seems that it was approved[1] and later revoked[2]
[1] https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/EUA%...
https://www.accessdata.fda.gov/drugsatfda_docs/nda/2020/EUA%20Review%20CQ%20HCQ.pdf
It seems HN is doing something to it.Oh, and it provides real references! (also, summaries both of the top papers answering your question, as well as each of the top papers individually, etc etc)
“Is C17orf69 related to cholesterol”
Vs
“How is C17orf69 related to cholesterol”
How questions by their nature can be lies. Been using chatgpt daily for medical questions but then I verify _everything_ it says via sources. It feels like 1998 Google in a way.
A dozen questions can save me tons of time. “My drunk college friend” who knows a lot but likes to boast that they know everything. Great for brainstorming, not great for fact checking.
I would absolutely love to try this model.
Excellent! Now I have a way to identify ChatGPT research papers!
The only catch? None of this exists! I couldn’t find the paper, couldn’t find the guy who allegedly wrote it, and couldn’t find the software (neither could pip or conda). When I asked for more details about the algorithm, it gave me something else meant for handling missing data instead.
On reflection, this is exactly what should have happened. I would have been thrilled to find something like that on StackOverflow or somebody’s blog, so it’s a great continuation of the prompt. It’s just not real!
Probing it about CenPCA it gave these two definitions:
"CenPCA is an abbreviation for Centralized Principal Component Analysis. It is a dimensionality reduction technique used in data analysis for compressing high-dimensional data into a lower-dimensional representation. The centralization step of CenPCA involves centering the data, making the first principal component aligned with the mean of the data. This makes it possible to capture the overall structure of the data and to highlight the most important patterns in the data set. CenPCA has been used in various applications such as finance, image processing, and bioinformatics to analyze large and complex datasets."
"CenPCA refers to "Centered PCA", which is a variant of Principal Component Analysis (PCA), a widely used method in machine learning and data analysis. The key difference between regular PCA and centered PCA is that in centered PCA, the data is first centered around the mean before performing the PCA, while in regular PCA, the mean is not subtracted from the data. This has implications in the interpretation of the results, as centered PCA can sometimes provide more meaningful principal components."
I would think there has to be something to this but it is confusing exact titles although I have had it make up python code that simply is nonsense also.
Another type of example I had was during a language philosophy discussion it recommended the paper:
"Language Evolution: The Hard Problems" by Morten H. Christiansen and Simon Kirby is a paper that explores some of the challenges and limitations of current theories of language evolution."
It was actually just a book called "Language Evolution" by Morten H. Christiansen and Simon Kirby but trying to find that exact paper title made me think it made it up.
I am tending towards becoming addicted to it still after massive frustration with it for things like this at first. It seems you just have to be careful when probing the outer edges of knowledge and to not get led down these nonsense paths.
Taking your example, 'Prompt Engineering' is becoming an increasingly important skill but I feel that everyone is winging it.
Is there any agreed scholar 'handbook' that synthesis the academia 'lessons learned' on this topic?
Now apply that to other topics...
What prevents it from doing the same when asked about research papers?
We saw similar stuff with the model that Meta released and quickly took down
I should note though that progress has been far faster than computer chess. We went from "An AI wont beat a Go champion for at least 30 years" to "AI beats Go champion" in two years.
Language and understanding abstract ideas is a bit more complicated than chess
I get what you mean, but that's also kind of silly. First, almost no one who is not in the field is going to be even asking it the kind of questions you are. Second, even if they do and try to use that as reasoning etc.. well, then that moron would basically find any type of source (i.e., random youtube video) to prove their "point".
So I honestly think the "harmful" argument is completely out the window. We already opened that pandoras box years ago with basically every piece of human knowledge online in so many places and people making videos on almost everything with all sorts of varying views.
People say this about the coding aspect as well "oh this is going to hurt the world because people will be just asking for code and it will be wrong!" Ok.. but it pretty much sounds like they were just going to do that anyway.
Let's focus on the positives of this infant technology that is still insanely impressive. We are just seeing the beginning, right?
Now we have a tool that isn't lying through malice, volition, or any sort of intent, and that will combine jargon and phrases that seem authoritative into its misinformation.
IMO responsible engineering involves considering the ups and downs of each solution - that's where the famous HA saying "if you have two you have one; if you have one you have none" comes from, dictating that we need at least 3 instances of a server for high-availability, right? What would it take to engineer this new tech for high accuracy? Where is anything other than the hubris of "we were so busy asking if we _could_, we never stopped to ask if we _should_" ?
I don't see how this will generate text that is comprehensive or useful. The open GPT models of that size aren't useable for text generation for anything serious. Adding the sensitivity of health/clinical I'd steer clear of this. Even BLOOM's model card specifically calls out biomedical as a misuse of the model [1].
[0] https://github.com/microsoft/BioGPT#news
[1] See "Out-of-scope" in https://huggingface.co/bigscience/bloom
[0] demo - https://labs.cactiml.com/medqa
[1] some screenshots and details - https://twitter.com/samarthrawal/status/1620545601296564228
Examples of what I tried:
> The SNP rs9651229 predicts multiple traits for humans. The predictions depend largely on the genotype. The TT genotype predicts the following traits:
This gives the same result as when I typed CC genotype instead.
> The following list contains all SNPs that predict depression:
This didn't list any SNP at all, and instead listed a bunch of things such as bipolar disorder
Most complex subjects require images and diagrams, and complex relationship between structure and form.....
https://www.youtube.com/watch?v=K0cmmKPklp4
For human students, the median score was 75.6%, ChatGPT performed slightly worse than a Columbia non-science major undergraduate, 73.9%.
Some of the errors was just messing up the arithmetics but it got the reasoning right.
The exam was a reply for this part:
> isn't even close to understanding scientific concepts and knowing how to connect them
That test in my book definitely proves that it can understand (or let's say process and create abstractions) scientific concepts and can place them on a knowledge graph.
> So what is really the utility of "testing" it?
Eventually these models will be integrated into everyday products so we need to learn how trustworthy they are. These tests are written in natural language, the same way everybody interacts with them.
If you really do think this stuff is important, show it on its own terms. Make tests suited for the model with rigorous expectations tuned for a computer, not a human. Then you can start showing some impressive things. I just urge you to see the basic flaw in your conceptions here. I don't want to rob you of your enthusiasm, just better direct it.
Nobody is saying that GPT-3 is smart. But it is surprisingly capable.
> Test's are useful precisely to gauge human retention/understanding
Indeed, and these models are also compressing information they were trained on. It makes sense to test them how well can we access and query that knowledge.
I'm not saying at all, that passing tests make them human or anything like us, but it speaks a lot about the quality of the model. It's not the ultimate quality check of course, but it's an important one, because you can assign a score to the results of the test.
> Its like applauding the calculator for doing math.
Show that calculator to Charles Babbage, he would be in awe :) This is probably the leap why most people are freaking out, it feels a significant step towards intelligent machines regardless of the system under the hood.
I actually tested ChatGPT, (like a few million other people). I'm not saying it was done with scientific rigour of course. It passed a few flawlessly and failed some other. I believe I know what I'm interacting with, I've read about how GPT works and I'm planning to learn more. Don't worry about my enthusiasm :)
> 7:36 The exam is structured with multiple choice questions at the start and then some freeform short answers towards the end.
Imagine if you could look up all material in the last 10 years published about astrophysics (or insert any major topic here) near instantly, the question's details are also presented for ingestion, then make prediction what is and is not based on weighing the frequency and potentially the source of information, and then respond in relatively coherent sentences.
There is no astrophysics in this.
That's why, if you want ChatGPT to actually think about a problem, you have to get it to give the explanation first, gradually, and only then output the answer. That way, GPT can use the rationale it has given in the prediction of the answer that fits best. If it has to give the answer first, it's already committed.
If a human has to answer a question, they follow a process like this:
- parse the question
- compute a rationale, and evaluate it to gain an answer
- output the answer first, because it's the most useful
- output the cached rationale.
But GPT trains left to right, and it cannot see the first two steps as they're not in the text. From its perspective, most humans produce answers and explanations simultaneously, instantaneously and intuitively. This makes it almost impossible for GPT to learn how to think. It has to rely on the very few samples where humans give the rationale first, and then the answer. And because this is rare, you have to really push GPT to actually use its scant cognitive abilities. ("Let's think about it step by step.")
Put otherwise, GPT doesn't interact with reality directly, but mediated through our language. But we also don't experience reality directly, so it's hard to see how much of a hindrance that would pose. Hell, much of our model of the world is just as rooted in language as GPT's. The part of my model of reality of which I have direct sensory experience is tiny.
Yes, but the human language is garbage. So while passing throught that filter without maintaining the highest degree of precision barely any of the actual reality remains. Truth sounds exactly the same as a lie.
The actual language that decently captures reality is math. Nothing less is even barely sufficient to produce almost anything but nonsense. Nonsense nicely sounding to human ears but still nonsense.
It certainly "knows" some stuff. However it can't reason about it.
There have been some articles on HN recently on how accurately LMs build world models.
I think the key bit here is that we can influence its associations by inputting the prompt, changing the model that is presented.
I'm waay ahead of myself here, but the thought is interesting, and it will likely remain an open question for at least a few months/years.
Which is actually a novel capability and arises because the network does reinforcement learning over its own context window. It's a strength, not a weakness. Humans can do the same thing. ("Assume that X...")
> It just randomly landed on correct thing first just because it seen it more often in the input data.
Isn't that just a description of learning?
It's true that the network has no idea what is "true". But it's not like we do either, all we do is learning from correlations. We're just better at it.
Humans who can't do math might be a pure language models though.
Under the hood it composes many calls to GPT-3 and other models in a big DAG workflow, parses things like "is this an RCT", "what was the effect size", "what critiques have other authors made about this paper".
Not affiliated, just think that it's a promising direction. You can read more about their motivation here: https://ought.org/elicit