Besides ZFS, VMware Workstation on Linux also interacts badly with transparent huge pages: https://unix.stackexchange.com/questions/679706/kcompacd0-us...
My "tune for vmware" script has grown to three lines over the years:
echo never > /sys/kernel/mm/transparent_hugepage/defrag
echo 0 > /sys/kernel/mm/transparent_hugepage/khugepaged/defrag
echo 1 > /proc/sys/vm/compaction_proactiveness # default 20