Often, people say that you should only automate things if it saves you time overall: spend 5 minutes writing a script only if it saves you 6 minutes. However, not all minutes are equal. 5 minutes when you are close to a deadline is far more valuable than 5 minutes when you are "idling".
For this reason, I always appreciate it if tools are written with automatability in mind, even if they may not save a lot of time when automated. If I have to use PyAutoGui for every automation I write, I think it will be a lot more brittle than I like. If it uses two-factor authentication, it makes the automation even less "flow-breaking".