Hah, you beat me to it; Hideo Kojima would be proud. Sounds like DARPA needs to start feeding old stealth video games into their robot's training data :)
https://metalgear.fandom.com/wiki/Research_and_development_a...
The only strategy that somewhat worked for me was perfect accuracy tranquilizer shots, to knock them out instantly. That's probably the hardest game mode I've ever played.
Halo 2 on Legendary difficulty was ludicrously hard too
On the other hand, I loved MGS3 on euro extreme! It really required mastering every trick in the game. Every little advantage you could squeeze into a boss fight was essential. Escape from Groznygrad was hell, though. By far the single hardest part of the game.