The daemon needs to be run as root root in a standard multi-user install which rules out HPC-like envs where Nix would actually shine. There are workarounds but none of them official.
Tooling and documentation are on the same level as for a random esoteric programming language. I love Nix but have been hesitant so far to push it at work despite immense productivity gains.
Similarly to HPC, Nix looks like a perfect match for CI/CD pipelines on the surface. In reality the only easy way to get it done is to use additional non-foss software [1].
[1]: https://discourse.nixos.org/t/recommendations-for-introducin...