VAC has a number of other triggers too but doesn't care about VMs in particular. I think everyone and their dog is an expert in not tripping VAC at this point

It's mostly those annoying ACs with kernel modules like EAC, BattlEye, ESEA etc. that do anti VM in an attempt to prevent cheat devs from 1. debugging the AC without at least a little effort and 2. having a clean OS but reading guest RAM from the host to avoid the anticheat entirely