Not an answer to your question, but just to shed light on the framing, it's slightly more abstracted than just a Node ORM - firstly it's Javascript and you can use it with any runtime other than Node, but it currently works with Go too and I believe their goal is to offer more languages in the future.

It's also a bit more abstracted on the 'data' side too. They offer a web interface, Prisma Studio, that abstracts over the physical database actually being used to allow you to do CRUD on the data. I think this is pretty useful.

In my mind (no connection to the company or knowledge beyond being a user) the business to be found there is in being the aggregation and intermediation layer of databases of different services, accessible to people with and without technical skills, in a uniform way.

It doesn’t have to in order to exist.