I'll go on a tweet made by a Twitter user with a large follower count and just start blocking people. AOC and Ilhan Omar are great because I can very easily pick out the crap comments being made just to try and troll them, I've started reading George Takei's tweets recently to block the trolling homophobes that respond to him.
Or at least that was the way in the past, haven't used twitter since a long while.
And the main purpose is to filter out all the pointless noise which existence has in the end absolutely no meaning for you. Keeping some of the clever expertised subtle manipulator in your timeline can be useful to better understand what is going on. You know like the people which aren't just misguided or afraid but are instead misguiding and outright deeply rooted evil knowing exactly how much pain and suffering their manipulative spiel will create.
Really applies to somewhere like Facebook too.
I didn't mean to cut off discussion or specific sides in a view point, but more to cut off sources of low-quality discussion. I do realize there's danger in how you categorize low quality too.