What about libraries and code-bases available to the programmer? Legacy code might not be a concern, but what about having to reinvent wheels?
I think no language is advanced enough to be used alone for everything. Steve Yeggie said that once a time at Amazon the only languages allowed were Lisp and C. It makes sense: an high level language plus a low level one. Those languages which try to encompass too much become too complex and hard to use effectively (think about C++).
When I started in 1997 (before Yegge) there was lots of C and Perl but no Lisp, at least not in the central repo. There were restrictions on Perl. The DBAs wouldn't let us use it to insert data in the database. Shel didn't care much for Perl. He might have warmed to it a little bit when he discovered it supported closures; I remember him sending a msg to the software alias about it.
Eric Benson had been a principal at Lucid, though I didn't know it at the time. Once he gave a class to the perlhackers on how to write code. The advice, as I recall, was to put "use strict;" at the top of our scripts and to start every function by shifting all the arguments into local variables. Eric Benson wrote the initial version of the "customer who bought this also bought..." code, and he used Perl, not Lisp. I'm sure he thought about the problem in Lisp terms, tho.