I regularly pick people up, but wouldn’t recommend it unless you’ve really given it thought.
For me - I’m a 6’2” bearded dude. I drive a Jeep and almost never have the doors or top on it in the summer. I’m also armed and have had some training.
Being in an open vehicle means that anyone around me in traffic can see what’s going on, so I’m reasonably confident a hitchhiker isn’t going to try to take me hostage or directly threaten me with a weapon. It also couldn’t be any better ventilated, so I’m able to pick people up whose “odor” would others make it difficult to get a ride.
I’ve probably picked up 100 or more hitchhikers at this point. I’ve had a couple that were obviously unhinged, more than a few people who were drunk or stoned to the point they had no business in public, and a surprising number of people who I would have never expected to take me up on my offer of a ride.
One of my favorite memories of this is when I found myself in Charlottesville, VA at about 1am, wide awake, in a growing snowstorm with nothing to do. My Jeep didn’t have doors or a top even though it was ~10ºF out. There was a little over a foot of snow on the ground, and the city buses had stopped as a result. I ended up driving back and forth all over downtown as the bars closed, taking college kids back to their homes when I found them stumbling through the snow trying walk back.
I often wonder how many of them woke up the next day questioning their own sanity. “How did I get home last night? I remember walking, then got a ride in a Go-Kart… Wait a sec - was that Hagrid driving!?”