I use screen regularly, but mostly to be able to attach and detach to sessions as I move between work, home, etc.
tmux users frequently tout its ability to do nifty split screens and other window management, but I'm not sure I understand the value of doing this over just starting another iterm2 window/tab and using regular window management tools. Cmd-tilde or Cmd-tab is one less key than Ctrl-a, h.... :) What am I missing?