For the rest, I run a pretty esoteric setup (compiled-from-source custom configured linux kernel with no binary blobs; all software compiled from source, with no exceptions; aggressive, burdonsome-to-me privilege separation; chroots and VMs for various degrees of potential threat; etc). I have no illusions that it is perfectly safe. What I am comfortable with is that, in order to compromise me, you would have to know a lot about what I run and how I run it. I believe that I would have to be nearly individually targeted to extract any useful data from my machine, and that I am not nearly a valuable enough target for anyone to do so. I think you would have to be a state-level actor or someone with similar capabilities to compromise me, and none of them would care enough.
My security paranoia stems from extremely sensitive work I did as a lawyer long ago, but I am now so used to it that I carry on as a scientist, even though my current work is not nearly so sensitive (if at all). I give up a lot of convenience and some functionality to operate this way, so it is not for everyone. I am not an adversary to anyone, so outside state actors surely don't care about me. And my own government can just get a warrant and knock on my door, so they don't care about me either.
Embedded device firmware besides the bios is probably my main vulnerability, but if you're successfully getting at me through my hard drives or mouse, then I was surely an incidental rather than actual target.