Nothing is divorced from nature, we are nature.
With that said, I think people who live in cities tend to feel plants, animals and ecosystems that are not ours less, and therefore we may be quite ignorant to the destruction we are causing.
It's one thing to know in the mind that we are destroying other life forms and it's another to live in that destruction.
Sure, depending on the measuring stick cities are more efficient. But I think most importantly, they likely aren't conducive to creating the sorts of empathy required for us to make decisions that are more in line with preserving other forms of life.
I don't quite know the answer, like many things existential...it's complex, confusing, nuanced and hard to grasp. I hope that we figure it out and I hope that I answer the call within me to join in that figuring out.