I have to use Chrome on a Mac because Safari refuses to support multiple profiles. I'm a fan of compartmentalization, so my side-business saved passwords are different than my personal saved passwords. Apple would prefer that I create two separate accounts on my Mac (and the annoyance of syncing dotfiles between the two), but Chrome just lets me switch between users seamlessly.

It seems like such an easy feature to add, but I'd bet there are Apple politics in play preventing Safari from adding this feature.