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Comment by Alex3917 | Hacker News Reader

> Can anyone more medically and scientifically literate provide some context to temper my doom and gloom?

Most of these issues stem back to endothelium damage. And the good news is that, in addition to taking all the vaccines you're eligible to get, there are a bunch of other things you can do to strengthen and protect your endothelium, e.g. doing HIIT and taking ACE inhibitors. The one risk we (afaik) don't really know how to mitigate is the risk of developing an autoimmune disorder, but this can happen after any viral illness and isn't necessarily a COVID-specific risk.

And in terms of reducing the risk of neurological issues, Palmitoylethanolamide seems to a least be much safer than NSAIDs, albeit expensive and still somewhat experimental.

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Except for me and many others long covid symptoms got worse after vaccination. Additionally new research is uncovering serious and significant risks for the vaccine with fairly marginal protection benefits.

> Additionally new research is uncovering serious and significant risks for the vaccine with fairly marginal protection benefits.

Could you provide a link to that research ?

https://www.sciencedirect.com/science/article/pii/S0264410X2...

https://jackanapes.substack.com/p/cdc-finally-released-its-v...

The study certainly doesn't support the claim of marginal benefits outweighing serious side effects.

https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.122.0...

> new research is uncovering serious and significant risks for the vaccine

The frequency of the reaction mentioned in this article is around 2 in 100,000 people.

The frequency of death from covid is somewhere in the range of 1000-2000 in 100,000 people.

I'll take the vaccine odds.

> with fairly marginal protection benefits

Your source says nothing about protection benefits being marginal.

In fact, one of the author's of this research said: "What the results don’t do, she stressed, is change the fact that the data strongly support getting vaccinated against COVID-19. “Clearly, developing postvaccine myocarditis is much more rare than developing any of the complications of infection with SARS-CoV-2,” she noted." https://www.tctmd.com/news/free-spike-protein-mrna-covid-19-...

As individuals those averages are looking at too large of a group. There are known subgroups with different risk profiles and grouping them together isnt helpful. You get very different risks from both for for example a healthy <30yo male and an obese >60yo male.

We have had that data for a while and simplifications serve no benefit. Its not early 2020 anymore, as always, as we get more accurate data, we get to adapt some strategies based on that.

edit: Not to mention the difference in strains (omicron vs delta) as well as the confidence into the different risks (under counting (detection problem) vs over counting(hospitalized/dying from vs with covid)

I suffered severe depression after getting the J&J vaccine - it wasn't even an mRNA vaccine. It became significantly harder to code and my brain felt like it had been dragged across concrete. Later it'd be stinging and I was dry heaving. Not fun.

I hate to ask - but what sort of research is available so far?

> Except for me and many others long covid symptoms got worse after vaccination.

Sure, because the MRNA spike protein appears to be rough on the endothelium even in healthy individuals, so it's easy to see why this could be problematic for people who already have vascular damage. But there are a lot of other long covid symptoms that folks have reported improving after getting vaccinated, e.g. loss of smell.

I assume this is collecting some downvotes because it's unclear if the second sentence is supposed to apply specifically to the long covid population or the general population.

Based on the submitted paper, if it is intended to apply specifically to the long covid population, then it seems to be a reasonable comment. It did mention post-long-covid vaccinations seemed to be more harmful than helpful - something like ~15% found their long covid symptoms improved afterwards while ~20% had their symptoms worsen.

If that second sentence was intended to apply to the general population, then it's neither supported nor contradicted by the submitted paper. I don't believe it addressed risks outside of those already suffering from long covid. While it did address protection against long covid, it didn't come to a particular conclusion on the matter. It mentioned that studies on this aren't in general agreement yet, and pointed out a number of potential reasons for this, such as varying and potentially incomplete standards for discriminating between both long covid and control groups, in addition to the basic difficulties involved in keeping up with new strains.

As for other research... well that's a whole other thing.

To clarify when I was making the comment I was thinking about vaccination and boosters for Covid recovered individuals with lingering symptoms associated with Covid.

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