It might "feel wrong" to set the heat pumps to 25°C, but that could easily be cheaper and more efficient than setting them to 20-21°C and supplementing to the same level of comfort with CoP of 1 resistive heating all season long.
If that won't work, for instance your home is very boxy and separated, it might be worth looking into AC duct boosters on the far away areas to suck more air out of the ducts from farther away.
If I misunderstood and you have a ductless system, they make electric fans that go in between paired walls and look like a ducted register, but that are very useful for blending air between two rooms. A few of those alongside a through floor to ceiling below fan duct might be available that could help even out temps in your house even more.
The indoor unit fan speeds are only loosely connected to this. (The higher the indoor fan speed, the greater the heat transfer and load on the compressor, all else being equal.)
My house has several "lifted ceilings" (15'/5m) and it is true that the heat from my minisplit units wants to accumulate up there. In some rooms we have ceiling fans that help move the air down (or up). In other rooms, there are no fans, and the upper part of the room space is indeed way, way hotter than the lower part, which is ridiculously inefficient.
HOWEVER ... this has never impacted the ability of the minisplit units to provide more than the same level of comfort as floor-mounted heating devices.
1. Make sure to point the vents down so the hot air blows into the lower area. (And naturally, in the summer when you use them for cooling they should point up)
2. Set a higher temperature. The thermometer tends to be part of the unit itself so it tends to measure the hottest spot in the room (both when heating and when cooling), so you think you are wasting money blasting the heat to 25C when actually it is just that the unit isn't running since it only keeps itself hot. Some units come with a function that pretends to use a thermometer built into the remote, but I don't think I've ever seen it do anything other than burn through the batteries.
3. Since you are talking about mini-split heat pumps (plural) I assume you have one per room so a good tip here would be to close the door to that room.
For my own needs they are more than enough, but then again it doesn't get quite as cold in Israel as it does in Canada :)
His heating and cooling bills are not far off from my house. Considering he has 3 buildings similar sized to my house it’s a pretty drastic reduction.
The main issue for me with air-X heat pumps is that over time it can start to make a lot of noise if not well maintained.
But the closed-circuit under-ground (or under-water) ones essentially don't need maintenance and are incredibly efficient, as the source never goes very cold.