Why is there an appendix? Obviously the back is flexible to allow freedom of movement, but that doesn't mean a person should pick things up by rounding their lower back or make it
more flexible. Another point is that nature did not make humans in order to have them sit in desks all day. In particular read the t-nation links in the OP.
I spend 15 mins or more of each workout combating the detrimental effects (incorrect pelvic tilt, shoulder impingement and rotation, etc...) of sitting at a desk most of the day.