You mean at the Python driver level? Unfortunately, that doesn't work with ctypes.

I've tried it by adding the DYLD_LIBRARY_PATH to os.environ before calling ctypes.LibraryLoader.LoadLibrary (https://docs.python.org/3/library/ctypes.html#ctypes.Library...) and it didn't work. I suspect ctypes gets somehow initialized much sooner and adding environment variables in your apps doesn't help.

TBH I didn't research it further, since the problems of the post are more general and it can happen that you trip into them regardless of runtime.