It’s probably not possible from a physics standpoint to replace motion induced pumping/diffusion with pure chemistry.
Its possibly people may isolate the two effects separately
This is kind of where I always have been, I find exercise to be a loathsome and boring chore, a necessary evil that gets in the way of things I would rather be doing.
It’s worth it for the global effect on my energy levels and health. But it remains true that for some of us, exercise is never a source of enjoyment, and I understand why many people can’t get through that to do it anyway.
I feel the same way with exercise. People tell me that you feel good after and I never do. People tell me that you feel a "good" soreness in your body and I never do. I just feel sore.
I wonder what's different about people like you and me where we don't enjoy this process the way some other people do? Do you think it's been studied?
The feeling after's nice, though. Would take that in a pill form, for sure.
I wish I felt like this. Exercise is tolerable when I'm doing something at the same time (walking, chatting, listening to music) but that's enjoyment despite the exercise, not because of it.
Reducing, stopping, counteracting mental decline is a holy grail in medicine. I think there has been some progress here.
And on the general mental acuity note there are things like modafinil.
The best things known work are do what you need to do to get good sleep, and find some way to exercise routinely.