Heads up to fzf users who used to use fzf's Ctrl+R, and would like to now disable it (to use fish's that has syntax highlighting) without disabling the rest of fzf's shell keybindings: I filed https://github.com/junegunn/fzf/issues/3115 , "How to selectively disable Ctrl+R shell keybinding (while NOT disabling Alt+C & others)"
EDIT faho (fish shell maintainer) chimed in the issue and describes how to ask fish to erase the custom binding after fzf keybindings load! I confirm it works :) . Pretty delicious fish. Thanks faho!
fzf_key_bindings # load fzf shell keybindings normally
bind --erase \cr # restore built-in-fish>=3.6.0 Ctrl+R history