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Comment by jjcon | Hacker News Reader

I think there is a good faith discussion though to be had about whether or not this could select for more deadly traits, no? That is certainly my first uneducated but good faith question that comes to mind after the past few years we’ve all been through.

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> there is a good faith discussion though to be had about whether or not this could select for more deadly traits, no

In the history of vaccination, has this ever happened?

What has happened is resistance to medicine. Vaccines reduce the opportunity for pathogens to be exposed to drugs by reducing the incidence and severity of illness.

It’s fine to take time to make informed medical decisions. But if your concern is resistance, vaccines are a friend.

Not with humans, but it has happened in chickens.

https://en.m.wikipedia.org/wiki/Marek%27s_disease#Prevention

It seems to be related to "leaky" vaccines.

Interesting. Curious why we haven’t seen a similar effect with SARS-CoV-2 or the poliovirus.

IIRC it took about 20 years to be apparent with Marek's disease.

The polio vaccines aren't "leaky", but we are seeing increasing problems with oral-vaccine-derived polio now: https://www.who.int/emergencies/disease-outbreak-news/item/2... - there are more cases of this than of "wild" polio nowadays.

> polio vaccines aren't "leaky"

Non-sterilising polio vaccines prevent illness but not infection and re-transmission. OPV is the one that sterilises.

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