I'm not sure if this is what you're looking for, but Grist has relationship-driven spreadsheets where the formulas are all Python code. And you can have multiple tables show on the same page, where selection of one filters the others.

The tables are more database-style than pure unstructured Excel sheet style, but I've found that having a full Python environment in each cell to be pretty powerful, and I've started turning to it for analytical work because I can avoid the mess that larger Excel formulas can turn into.

No relationship except as a customer -- they're at getgrist.com