Have you looked at what's happened in Bentonville in the last few years? The cycling infrastructure that's been built extends well beyond the core and does a remarkable job connecting the suburban style development with the downtown core.
They've built miles and miles of greenways and off street bike paths. I was there three months ago and rode all over town without once feeling threatened by auto traffic. Is it perfect? No, absolutely not. But I defy anyone to go there, ride their bike to commute around, and walk away thinking "getting around by bike in in the US is impossible."
I don't think Bentonville is repeatable everywhere, and it may even be a fluke, but it's certainly proof that it can be done.