Another fat guy here. I haven't taken any of these drugs, but I stopped eating processed food (or anything with added sugar), avoided late night snacks, and lost around 30 pounds in 8 months as a result. I had the fatigue and such early in the process, but it sorted itself out eventually. The most important thing I recognized was that if I avoided eating late at night, I didn't feel awful waking up in the morning. I'm embarrassed to say it took more than a year to change my behavior, despite my clear understanding of the harm of snacking all the time.