What I envision is having one master key combination to pull up a panel or overlay of some sort, which displays which key I press next to go to a certain place, or do a certain action. So there's just one thing to memorize.
Sort of like how vimium works in browser, where you press 'f', and each clickable gets a little label. (But preferably not randomly assigned)
The memorizing-most-commonly-used-50-keyboard-combination thing really doesn't work for me, whether it's home row or function keys. I mean, I still have to look at the little pictures for stove knobs after years of using the same stove, and that's just four knobs.