I've been doing this for >10 years with https://manytricks.com/butler/. Works great! You can also bind snippets of text, scripts, etc.

I can't overstate how important it is to have a keyboard that groups function keys into "islands" of (generally) 4 so you can touch-type them. An ergonomics consultant once observed that the source of my neck pain was that I looked at the keyboard while typing. As a touch-typist, I found this puzzling—until we realized it was just the function keys. :-)

Btw, LaunchBar (https://obdev.at/products/launchbar/index.html) makes an excellent 2nd-level util for things not common enough to merit a single keychord.

Never tried it myself, but https://github.com/koekeishiya/yabai comes to mind

As others have mentioned yabai +skhd is excellent. I think using this guide to set it all up went a long way for me: https://cbrgm.net/post/2021-05-5-setup-macos/

Yabai is my daily driver and I really like it.

Yabai is quite decent.