Constant matters. Ahead-of-time compilation (AOT) and just-in-time compilation (JIT) are a lot faster than interpretation [1,2], sometimes by a factor of >100 in the case of C vs pure python [3]. This gap is noticeable for a program taking more than a few seconds to run. Except for performance-critical tasks, my preference is JIT-based languages without a manual compilation step, such as LuaJIT, Javascript-V8/Node.js and Dart. Nonetheless, these language implementations are much harder to develop than interpreters.
[1] https://benchmarksgame-team.pages.debian.net/benchmarksgame/...
[2] https://benchmarksgame-team.pages.debian.net/benchmarksgame/...
[3] https://benchmarksgame-team.pages.debian.net/benchmarksgame/...