I can't be the only one that very often have my left hand on the (left part of the) keyboard and the right on the mouse doing a lot of shortcuts while navigating the GUI.

Such as ctrl+z, ctrl+c, ctrl+v, ctrl+w, ctrl+t, ctrl+n, ctrl+s that requires two hands on dvorak ("especially" on an ergonomic keyboard) - or at least requires the right hand (=> you can't use the mouse) or you have to reposition the left hand (not acceptable).

This is not something that you can just relearn and this is something that seriously hinders at least my workflow.