I'm researching Responsive Web Design as an option for a large e-commerce site. But for me, for a large site with a lot of dynamic content and functionality, it doesn't seem ideal to simply shrink it down to one column.
And I also wonder about the amount of time it takes to create designs taking all screen sizes into consideration.
Anyways, thanks again.
Also, responsive design doesn't have to be about getting your website to work on your 2001 Nokia brick's display. A good first step in responsive design is just to take advantage of the full width of the device your user is using up until a point. A lot of websites I view from my netbook could take advantage of just one media query: a full-sized design for large screens and then a fluid width design for anything smaller. I find a lot of websites give me a horizontal scrollbar on the 10' screen.