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Like all web apps it depends on how much you want to do on the client side vs. the server side. With blockchain apps it is now client side vs. server side vs. blockchain side.

At one extreme, apps like UniSwap are mostly blockchain side and server side code and a little client side.

At the other extreme, it is possible to use boilerplate code to write a minimal blockchain part and then have most of your business logic on your own server and then the UI on the client side.

There is also Vyper and Fe. But they are both much less mature, probably not recommended for production.

There are other languages that compile to EVM bytecode, but: probably yes.

none of them are ad aptly named as Pyramid Scheme[0]

[0] http://www.michaelburge.us/2017/11/28/write-your-next-ethere...