Yesterday I was trying to make an ebook out of a comic I made, where there is one image per page. The designers of epub and mobi apparently didn't think it useful to be able to put an image in the center of a page, it has to be glued to the top. That seems so idiotic that I'm still hoping I didn't look well enough.
I'm also trying to find an easy way to make a book into an android and iphone app. O'reilly packages some of its books as apps using the aldiko reader, but I haven't found any explanation about how to do this.