CS like other disciplines will be dominated by the climate change fallout for the next 100 years. One thing I think about is that for the entire history of computing there have always been more programmers this year than the last. The number of programmers on the planet has always been increasing.
What happens when that trend reverses? Better yet, what happens when the number of people who are capable of writing software plummets quickly due to a mass extinction event?
What kinds of systems will the survivors design and implement? How will the relationship between development and maintenance change in this new world?