Until Acrobat, Photoshop, and Illustrator work in Wine, it's a hard no.

Word and Excel are good :) plus there are tolerable replacements. Outlook is buggy as hell, but evolution can do its job.

But when I need to fill out and digitally sign a PDF form - something that should be an easy and mundane task - the entire Linux ecosystem fails me.

Also, task prioritization is still horrible. I fire up a high CPU background task and the mouse cursor stutters? (in GNOME)