Andrew Huberman's interview with researcher David Sinclair mid-2022 well worth a listen for high level but technical coverage of state of play.
Yes, these people are avid promoters of their work, but they are doing the work.
Maximum lifespan is unimportant anyway. What actually matters is healthspan. If anything we're going backwards on that metric.
Same thing with extending human lifespan to 150. Let's see some actual scientific evidence. Otherwise it's just an expression of faith.
In 2004, Sinclair, along with serial entrepreneur Andrew Perlman, Christoph Westphal, Richard Aldrich, Richard Pops, and Paul Schimmel, founded Sirtris Pharmaceuticals. Sirtris was focused on developing Sinclair's research into activators of sirtuins, work that began in the Guarente lab. The company was specifically focused on resveratrol formulations and derivatives as activators of the SIRT1 enzyme; Sinclair became known for making statements about resveratrol like: "(It's) as close to a miraculous molecule as you can find. ... One hundred years from now, people may be taking these molecules on a daily basis to prevent heart disease, stroke, and cancer." Most of the anti-aging field was more cautious, especially with regard to what else resveratrol might do in the body and its lack of bioavailability. The company's initial product was called SRT501, and was a formulation of resveratrol. Five years later, GSK shuttered the Sirtris program without successful drug development.
Sinclair broadly discusses his longevity practices on social media and includes them in his book. They include daily doses of NMN and resveratrol, which Sinclair says are activators of SIRT1.
Studies published in 2009 and early 2010 by scientists from Amgen and Pfizer cast doubt on whether SIRT1 was directly activated by resveratrol and showed that the apparent activity was actually due to a fluorescent reagent used in the experiments.
https://en.wikipedia.org/wiki/David_A._Sinclair https://en.wikipedia.org/wiki/Sirtris_Pharmaceuticals
what distinguishes those people?