I'm curious as to the scope of this, and what end products are effected. A lot of the best-in-class greases (krytox) and orings (FFKM aka kalrez) rely heavily on fluoro-components. FFKM orings in particular are head and shoulders above everything else by ~100C worth of working temperature range. FKM 'Viton' orings are also incredibly popular and are widely used in automotive applications for temperature and oil resistance in addition to having major industrial uses.
[0]Fluorine is a real PITA to produce and make derivatives from - environmental issues aside functionally equivalent non-fluorine compounds would almost always be cheaper.