While the findings are interesting and may hold therapeutic potential, this is a very zoomed in perspective.

We know that epigenetic changes occur in microgravity and they occur across the entire genome. While one gene may see an upregulation or downregulation, it's important to know this happens to many genes i.e. differentially methylated regions (DMRs). And these DMRs are not entirely predictable as there are many mechanisms associated with epigenetics. For example, two species at different levels of maturity may exhibit different DMRs in microgravity.

So while we may see downregulation in one age-related gene, you may very well see an upregulation of the many other age-related genes. We'll have to find out with further inquiry.

Still, very cool stuff and I hope more funding goes into microgravity effect on gene expression.