In the USA on a government level? No idea, at least it isn't a thing around where I live, but I also sit at home and get paid to write software. No idea what applying for jobs in some industries might look like.

On the social level? People have fractured families over it and/or forced(you can't see your grand children unless you're vaxxed, for example)/coerced family members into getting it despite their otherwise refusal. I still know people who won't let non vaccinated people come over for events. It's a much rarer thing now, but the damage has been done.