I am perfectly comfortable (and therefore want my system to turn off) after my AC has been running long enough to drop the humidity a bit, even if the temp has only dropped a fraction of a degree. As humid air leaks in, I want the AC back on even if the temp has barely increased a degree. Basically the heat index in my house swings enough to change my comfort and therefore could be a useful trigger, even if the temperature doesn't swing nearly enough to be a useful trigger.
The Nest even has a humidity sensor, but it only gets used in very specific (hardly useful) situations.
I considered writing a Works With Nest app for this. Then that platform disappeared in favor of Works With Google, but I never found the time for either...