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Sadly?

I prefer desktop Windows programs to be gdi/win32, they are often the most thought out and optimized for actual desktop paradigms (i.e mouse+keyboard+high res screen) without giant margins, padding and whitespace everywhere and makes use of proper desktop class widgets like treeviews, listviews, tabs, etc.

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Exactly. Haters gonna hate me but I really liked Windows.Forms (and C#) for development line-of-business desktop apps.

Nah, still quite good, although I personally would go with WPF, Forms is also quite good for what still matters on Windows desktop, just note that on the new runtime (.NET Core) there are still some issues with the out of process designer.

Windows offers multiple and mixed paradigms though, so ideally the UI needs to be able to adapt to and handle these paradigms

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