Depends strongly on the drive, with a lot of variance, and seedy vendors.
You can get effectively NVME over USB. Now, the question is, are you using a 5 or 10mbps (or higher with TB/usb4) connection, supported cable, is there a hub in the way restricting traffic, etc.
With most computers, the front ports may or may not be the fastest ports. If there's a front panel USB C connection, that's usually your best bet, then red/yellow ports in the back... Of course, it could be an older device/interface, etc.
I kind of hope that with USB5, they standardize on labelling/cable requirements as well as reduce the "optional" bits to at least fall under one of 2-3 umbrella sets of requirements. It's a bit of a mess.
All of that said, I have nvme drives over USB that are at least as fast as a SATA connected drive, and generally much faster depending on the port used.