The hosts give advice to real problems sent in by listeners involving non-technical issues in the software engineering workplace, such as dealing with problematic co-workers, how best to develop your skills into seniority, how and when to negotiate a pay raise and how to prepare yourself for moving to another job.
I don't think every episode is extremely useful since a lot of the solutions for workplace related problems can be drilled down to "look for a new job and quit your old one", but the hosts are very charismatic and funny. And when they do give good advice it's always something I've kept in mind which has occassionally helped me in my own job.