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I believe this is not unique to a lot of people unfortunately.

Loads of friends != satisfaction from the sense of belonging and meaning.

I don't have an answer for you, but just trying to get to people where you can have meaningful and thoughtful conversations helps a lot for the belonging. Alternatively, a therapist should definitely help here to at least find ways.

It seems like there are a lot of men health communities these days focusing on this issue as well.

Is there a reason you have loads of friends but still feel lonely? Do you think it stems from something you can control, such as having deeper conversations with them, and opening up more?

Well at least you got a family and friends.

friends is different than acquittances

I agree, but acquaintance always sounds really stilted in a casual conversation, so I use the word friend in a wider context depending on the situation.