I'd be happy using Safari, but the deal-breaker for me is the lack of uBlock Origin. There are other suggestions that people mention - Ghostery and Wipr for example - but somehow they don't give me confidence that they're going to be as reliable.
It’s not perfect but the balance of effort versus results is pretty good imho. The only thing I really miss is being able to disable JS per site, instead of globally, which Safari doesn’t allow :/