He got incredibly lonely, lost all his friend, and got ostracized over posting some alt right and Q shit on twitter.
It seems to me he's reasonably happy, especially considering his circumstances were far from happy before Minecraft - his parents were ex-addicts, he had himself dropped out of school, his father had a mood disorder and relapsed into drug use and killed himself just weeks after the first big Minecon.
Most of us don't lose all our friends, or go in the deep end alt-right in our 20's...