Ask HN: Starting Game Development

I assume you have some knowledge of C# and .NET derivates, if that, you can first give a try to XNA [1], as it is more robust and resourceful than web frameworks are at the moment. And when you feel you're ready you can switch to browsers.

1. http://en.wikipedia.org/wiki/Microsoft_XNA

iPhone\iOS best platform for indie development at now (best profit). Flash also is good. May be Android not so bad. HTML5, JS, Win phones, bada phones etc - is very depending on type of project.

Have you tried Unity3D?

http://unity3d.com/