ISO is basically a linear gain that's done on the sensor. As long as you aren't blowing out your photo and loosing information, it basically makes not difference if you do it in sensor or later while editing
So the only variable left is the shutter speed - which is basically directly dictated by the amount of light you have. You try to get as much light as you can without blowing anything out. This is how you get the most information. You can decrease it to get faster shots with less blur, at the cost of more noise
So it all boils down to basically one "slider"/variable between blur and noise