I would have thought this obvious and it's essentially my experience (and I'm definitely not a plumber). However, I've found that more PTFE tape is needed on old or worn fittings or on ones that have damaged or badly cut threads—or when mating same sized pipes/fittings but each with different threads (yes, that's a desperate brute-force move in an emergency but I've had to force such matings on more than one occasion). In these circumstances, I'll use two or three turns or more often by trial and error—and this changes somewhat depending on whether I'm using thinner white PTFE tape or the thicker pink one.
Of course—not being plumber—it often happens that when I urgently need PTFE tape I cannot find it (it having been filed in some obscure place that I've forgotten about—even though I keep a reasonable stock of it), it's then I fall back to the good old combination of Hessian/burlap jute-type rope (of which there is always some lying around in my workshop) and linseed oil based paint. It's messy and much less convenient combination than PTFE tape but it still works wonderfully well. Moreover, it's more tolerant of the amount applied as the linseed oil actually binds to the pipe surface as opposed to the more 'mechanical' bond of the PTFE.