Basically any JetBrains IDE.

They always work with minimal configuration for me, and just generally make all of the tedious stuff take less time. Being able to do everything I need to do (building, running tests, debugging, interfacing with a db, HTTP requests, refactoring, static analysis, VCS tasks) in one place just feels good to me. Also, I have yet to see another IDE with something like IntelliJ's Structural Search and Replace.

I use emacs on the command line for brief edits, but I've never managed to find an IDE-esque setup for it that worked well (I've struggled just to have it indent Python the way I want it to).