So, I think this is one of those things where YMMV is very much true. That said, I have a lot of wrist/thumb issues and am heavily invested in ergonomics to mitigate said issues and prevent them from worsening. I also wear a large watch every day while using a computer, and I experienced at times exactly what you're referring to.
Ultimately, it came down to the band. The only bands I found that would not cause issues were bands like the milanese loop for the Apple Watch, the trail band for the Apple Watch Ultra, or similar designs, where these bands have flexibility and are capable of sliding/slipping in a controlled fashion to "self-adjust".
The issue with other watch bands type like a typical plastic sports band or metal link bracelet, are that they have no flexibility. What happens is that when your wrist flexes and the band doesn't give way, is that it creates pressure on the tendons and you can end up getting a form of RSI. Much more flexible bands give way and allow your watch to adjust over time to the position of where your hands need to be for typing. When using a milanese loop style band I even noticed I would need to tighten it again when I'd stand up to walk around as it'd be a bit loose, and it'd hold its position until I sat to type again. That it's significant enough to be noticeable is indicative that it's quite a lot of required flexibility.
Rather than giving up on wearing a watch, I'd recommend you spend some time trying different bands and look for flexible bands.